The CSIR and the University of Pretoria have developed a bioreactor system with perfluorocarbon nano-emulsion oxygen carrier that can be used in fields such as drug screening and for bio-artificial liver support.
Technical Field/Operating Unit or Centre:
Biotechnology, medical devices / CSIR Materials Science and Manufacturing
Technology available for license
Acute liver failure still has an 80% mortality rate, and liver transplants are currently the only real solution available. There is also a general shortage of donor organs. The CSIR and the University of Pretoria have developed a Bioartificial Liver Support Systems which contains a liver cell (hepatocyte) bio-reactor. The patient’s blood plasma is circulated through this system for the cells to perform metabolic, regulatory and clearance functions.
Several patents have been granted and a strong research platform also exists. The key aspect of the core invention is a nano-emulsion oxygen carrier based on perfluorocarbons. This has other potential applications, including in organ preservation (warm perfusion of organs for transplant), which is being explored via further collaborations.
- Bio-artificial liver support
- 3D Cell-culturing
- Drug screening
- Tissue engineering
Benefits / Advantages:
Use of PFC for oxygenation of cells provides support for high-density cell culture with increased cell function.
Patents covering the BALSS have been granted in Canada, France, Germany, Spain, UK, Netherlands, China, India, Italy, Korea, South Africa and the USA. A patent application is pending in Brazil.
Contact: Delon Mudaly